For research use only. Not for therapeutic Use.
KRAS G12D Inhibitor 14（Cat No.:I044045）is a selective small-molecule inhibitor targeting the oncogenic KRAS G12D mutation, a driver mutation commonly found in pancreatic, colorectal, and lung cancers. By specifically binding to the mutant KRAS G12D protein, this compound blocks downstream signaling through the MAPK and PI3K pathways, suppressing tumor cell proliferation and survival. Unlike pan-KRAS inhibitors, it offers mutation-specific targeting with reduced off-target effects. KRAS G12D Inhibitor 14 is a valuable tool for cancer research focused on precision therapy, enabling studies on therapeutic resistance and targeted inhibition of mutant RAS signaling.
| CAS Number | 2765254-39-3 |
| Synonyms | 4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-6-[2-methoxy-5-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine |
| Molecular Formula | C20H19F3N4OS |
| Purity | ≥95% |
| IUPAC Name | 4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-6-[2-methoxy-5-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine |
| InChI | InChI=1S/C20H19F3N4OS/c1-28-16-5-2-11(20(21,22)23)6-14(16)17-7-15-18(25-10-26-19(15)29-17)27-9-12-3-4-13(27)8-24-12/h2,5-7,10,12-13,24H,3-4,8-9H2,1H3 |
| InChIKey | DYYANULKLUNJSO-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C=C1)C(F)(F)F)C2=CC3=C(N=CN=C3S2)N4CC5CCC4CN5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
