KRAS G12D inhibitor 1

• CAT Number: I044541
• CAS Number: 2621928-43-4
• Molecular Formula: C33H32F2N6O2
• Molecular Weight: 582.64
• Purity: ≥95%
• Synonyms: 4-[4-(3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-[[(2R,8S)-2-fluoro-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynylnaphthalen-2-ol
• IUPAC Name: 4-[4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[[(2R,8S)-2-fluoro-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynylnaphthalen-2-ol
• InChI: InChI=1S/C33H32F2N6O2/c1-2-19-5-3-6-20-11-24(42)12-25(27(19)20)29-28(35)30-26(14-36-29)31(40-16-22-7-8-23(17-40)37-22)39-32(38-30)43-18-33-9-4-10-41(33)15-21(34)13-33/h1,3,5-6,11-12,14,21-23,37,42H,4,7-10,13,15-18H2/t21-,22-,23+,33+/m1/s1
• InChIKey: HQVNRYKTWPMSGZ-LLXWCGCWSA-N
• SMILES: C#CC1=CC=CC2=CC(=CC(=C21)C3=NC=C4C(=C3F)N=C(N=C4N5C[C@H]6CC[C@@H](C5)N6)OC[C@@]78CCCN7C[C@@H](C8)F)O

KRAS G12D inhibitor 1（Cat No.:I044541）is a selective small-molecule inhibitor targeting the KRAS G12D mutation, a common oncogenic driver in pancreatic, colorectal, and lung cancers. This inhibitor binds specifically to the mutant KRAS protein, interfering with its GTP-bound active state and downstream signaling through the MAPK and PI3K pathways. By selectively targeting KRAS G12D, it induces anti-proliferative effects in cancer cells while sparing wild-type KRAS. Preclinical studies show promising tumor regression and pathway inhibition. KRAS G12D inhibitor 1 represents a significant advancement in precision oncology targeting previously “undruggable” RAS mutations.