For research use only. Not for therapeutic Use.
KRAS G12C inhibitor 28（Cat No.:I044086）is a selective small-molecule inhibitor designed to target the KRAS G12C mutant, a common oncogenic driver in non-small cell lung cancer (NSCLC) and other malignancies. It binds covalently to the cysteine residue introduced by the G12C mutation, locking KRAS in its inactive GDP-bound state and blocking downstream MAPK signaling. KRAS G12C inhibitor 28 is widely used in cancer research to study mutant-specific signaling, drug resistance mechanisms, and combination strategies with immune checkpoint inhibitors or MAPK pathway modulators. It supports the development of precision therapies for KRAS-driven cancers.
| CAS Number | 2649004-88-4 |
| Synonyms | 1-(4-dimethylphosphoryl-2-methyl-6-propan-2-ylphenyl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one |
| Molecular Formula | C33H36F2N5O4P |
| Purity | ≥95% |
| IUPAC Name | 1-(4-dimethylphosphoryl-2-methyl-6-propan-2-ylphenyl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one |
| InChI | InChI=1S/C33H36F2N5O4P/c1-8-27(42)38-12-13-39(20(5)17-38)31-23-16-25(35)29(28-24(34)10-9-11-26(28)41)36-32(23)40(33(43)37-31)30-19(4)14-21(45(6,7)44)15-22(30)18(2)3/h8-11,14-16,18,20,41H,1,12-13,17H2,2-7H3/t20-/m0/s1 |
| InChIKey | AULVAQHFJPQQED-FQEVSTJZSA-N |
| SMILES | C[C@H]1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=C(C=C5C)P(=O)(C)C)C(C)C)C(=O)C=C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
