KRA-533

• CAT Number: I030151
• CAS Number: 10161-87-2
• Molecular Formula: C13H16BrNO3
• Molecular Weight: 314.18
• Purity: ≥95%
• Synonyms: 4-[4-[(2-bromoacetyl)amino]butyl]benzoic acid
• InChI: InChI=1S/C13H16BrNO3/c14-9-12(16)15-8-2-1-3-10-4-6-11(7-5-10)13(17)18/h4-7H,1-3,8-9H2,(H,15,16)(H,17,18)
• InChIKey: WZQJLTLURXNPQG-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1CCCCNC(=O)CBr)C(=O)O

KRA-533（Cat No.:I030151）is a unique small-molecule KRAS agonist that binds to the GTP/GDP-binding pocket of KRAS, inhibiting GTP hydrolysis and promoting accumulation of active GTP-bound KRAS. Unlike inhibitors, it hyperactivates both wild-type and mutant KRAS (e.g., G12C, G13D), leading to persistent ERK pathway signaling. This overstimulation induces apoptotic and autophagic cell death in KRAS-mutant cancer cells. In preclinical models, KRA-533 effectively reduces tumor growth without significant toxicity. With a molecular weight of 314.18 g/mol, it serves as a valuable tool for studying KRAS-driven cancers and non-traditional therapeutic strategies.