Kp7-6

• CAT Number: I040420
• CAS Number: 629628-53-1
• Molecular Formula: C48H56N10O15S2
• Molecular Weight: 1077.15
• Purity: ≥95%
• Synonyms: (2S)-2-[[(4R,7S,10S,13S,16S,19R)-19-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-7-benzyl-13-(2-carboxyethyl)-16-(carboxymethyl)-10-(1H-imidazol-5-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-(4-hydroxyphenyl)propanoic acid
• InChI: InChI=1S/C48H56N10O15S2/c49-31(16-26-6-10-29(59)11-7-26)41(65)57-37-22-74-75-23-38(47(71)56-36(48(72)73)18-27-8-12-30(60)13-9-27)58-43(67)33(17-25-4-2-1-3-5-25)53-44(68)34(19-28-21-50-24-51-28)54-42(66)32(14-15-39(61)62)52-45(69)35(20-40(63)64)55-46(37)70/h1-13,21,24,31-38,59-60H,14-20,22-23,49H2,(H,50,51)(H,52,69)(H,53,68)(H,54,66)(H,55,70)(H,56,71)(H,57,65)(H,58,67)(H,61,62)(H,63,64)(H,72,73)/t31-,32-,33-,34-,35-,36-,37-,38-/m0/s1
• InChIKey: FXIRLIREUIBHCF-QSVFAHTRSA-N
• SMILES: C1C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSS1)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)O)CC3=CC=CC=C3)CC4=CN=CN4)CCC(=O)O)CC(=O)O)NC(=O)C(CC5=CC=C(C=C5)O)N

Kp7-6(CAT: I040420) is a synthetic Fas mimetic peptide that functions as a Fas/FasL (Fas ligand) antagonist, effectively blocking Fas-mediated apoptotic signaling. By interfering with the Fas–FasL interaction, Kp7-6 inhibits downstream caspase activation and protects cells from programmed cell death. It has demonstrated protective effects in vivo, notably preventing Fas-induced hepatic injury in murine models. Kp7-6 is a valuable tool for studying apoptosis, immune regulation, and tissue damage associated with excessive Fas signaling. Its therapeutic potential extends to research in autoimmune diseases, liver disorders, and other pathological conditions involving Fas-mediated cell death pathways. Ideal for in vitro and in vivo apoptosis studies.