KNT-127

• CAT Number: I030122
• CAS Number: 1256921-89-7
• Molecular Formula: C24H24N2O2
• Molecular Weight: 372.46
• Purity: ≥95%
• Synonyms: (1R,14S,15R)-25-methyl-4,25-diazahexacyclo[13.7.3.01,14.03,12.05,10.017,22]pentacosa-3,5,7,9,11,17(22),18,20-octaene-14,20-diol
• InChI: InChI=1S/C24H24N2O2/c1-26-9-8-23-14-21-17(10-16-4-2-3-5-20(16)25-21)13-24(23,28)22(26)11-15-6-7-18(27)12-19(15)23/h2-7,10,12,22,27-28H,8-9,11,13-14H2,1H3/t22-,23-,24-/m1/s1
• InChIKey: NFXFNBIPWUYEIM-WXFUMESZSA-N
• SMILES: CN1CC[C@]23CC4=NC5=CC=CC=C5C=C4C[C@]2([C@H]1CC6=C3C=C(C=C6)O)O

KNT-127（Cat No.:I030122）is a selective and potent agonist of the delta opioid receptor (DOR), a receptor involved in modulating pain, mood, and neuroprotection. Unlike traditional opioids, KNT-127 exhibits minimal abuse potential and reduced side effects, making it a promising candidate for safer pain management and psychiatric therapies. It has shown antidepressant- and anxiolytic-like effects in preclinical models without inducing sedation or tolerance. KNT-127 is also being investigated for its neuroprotective properties in conditions like Parkinson’s and Alzheimer’s diseases. Its high selectivity and efficacy make it a valuable tool in neuropharmacological research.