KN-93 Phosphate

• CAT Number: I011136
• CAS Number: 1188890-41-6
• Molecular Formula: C26 H29 Cl N2 O4 S . H3 O4 P
• Molecular Weight: 599.03
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• IUPAC Name: N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide;phosphoric acid
• InChI: InChI=1S/C26H29ClN2O4S.H3O4P/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25;1-5(2,3)4/h3-16,30H,17-20H2,1-2H3;(H3,1,2,3,4)/b6-5+
• InChIKey: NNKJTPOXLIILMB-IPZCTEOASA-N
• SMILES: CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC.OP(=O)(O)O

KN-93 phosphate（Cat No.:I011136）is a selective, cell-permeable inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII), with the molecular formula C26H32ClN2O8PS. It is commonly used in biochemical and cellular research to study CaMKII-mediated signaling pathways involved in memory, synaptic plasticity, cardiac function, and immune responses. KN-93 phosphate blocks CaMKII autophosphorylation, thereby modulating calcium signaling without affecting upstream calmodulin activity. It is water-soluble and often used in in vitro and in vivo models. Care should be taken to distinguish its effects from those of its inactive analog, KN-92, for experimental control and specificity.