KMH-233

• CAT Number: I030109
• CAS Number: 1941174-13-5
• Molecular Formula: C32H25N7O5
• Molecular Weight: 587.58
• Purity: ≥95%
• Synonyms: (2S)-2-amino-3-[3-[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]carbamoyl]phenyl]propanoic acid
• InChI: InChI=1S/C32H25N7O5/c1-36-27(40)17-44-21-11-9-19(10-12-21)28-22(15-33)29-37-25-7-2-3-8-26(25)39(29)30(23(28)16-34)38-31(41)20-6-4-5-18(13-20)14-24(35)32(42)43/h2-13,24H,14,17,35H2,1H3,(H,36,40)(H,38,41)(H,42,43)/t24-/m0/s1
• InChIKey: MLNOOVGSMCJSCE-DEOSSOPVSA-N
• SMILES: CNC(=O)COC1=CC=C(C=C1)C2=C(C3=NC4=CC=CC=C4N3C(=C2C#N)NC(=O)C5=CC=CC(=C5)CC(C(=O)O)N)C#N

KMH-233 (Cat No.: I030109) is a selective CB2 cannabinoid receptor agonist widely used in pharmacological and biomedical research. By preferentially targeting CB2 over CB1 receptors, it enables the study of immune modulation, inflammation, and pain pathways without strong psychoactive effects. KMH-233 has been applied to explore the therapeutic potential of CB2 activation in conditions such as autoimmune diseases, chronic pain, and neuroinflammation. Its receptor selectivity makes it a valuable chemical tool for dissecting endocannabinoid system mechanisms and advancing drug discovery research.

Reference

[1]. Huttunen KM, et al. A Selective and Slowly Reversible Inhibitor of l-Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells. J Med Chem. 2016;59(12):5740-5751.
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