KMG-301AM TFA

• CAT Number: I040088
• CAS Number: 1372642-78-8
• Molecular Formula: C32H28F3N3O8
• Molecular Weight: 639.58
• Purity: ≥95%
• Synonyms: [9-[3-(acetyloxymethoxycarbonyl)-4-oxoquinolizin-1-yl]-6-(dimethylamino)xanthen-3-ylidene]-dimethylazanium;2,2,2-trifluoroacetate
• InChI: InChI=1S/C30H28N3O6.C2HF3O2/c1-18(34)37-17-38-30(36)24-16-23(25-8-6-7-13-33(25)29(24)35)28-21-11-9-19(31(2)3)14-26(21)39-27-15-20(32(4)5)10-12-22(27)28;3-2(4,5)1(6)7/h6-16H,17H2,1-5H3;(H,6,7)/q+1;/p-1
• InChIKey: NMFWYDTXAWHNRE-UHFFFAOYSA-M
• SMILES: CC(=O)OCOC(=O)C1=CC(=C2C=CC=CN2C1=O)C3=C4C=CC(=[N+](C)C)C=C4OC5=C3C=CC(=C5)N(C)C.C(=O)(C(F)(F)F)[O-]

KMG-301AM TFA (Cat No.: I040088) is a small-molecule compound under investigation for its potential role in modulating immune responses, specifically targeting key immune checkpoints or signaling pathways involved in cancer and autoimmune diseases. The compound may work by enhancing immune cell activation or inhibiting immune suppression within the tumor microenvironment. The TFA (trifluoroacetate) salt form improves its stability and solubility for research purposes. Preclinical studies suggest KMG-301AM TFA could be useful in cancer immunotherapy, though further clinical evaluation is required to determine its therapeutic potential.

Reference

[1]. Shindo Y, et al. Newly developed Mg2+-selective fluorescent probe enables visualization of Mg2+ dynamics in mitochondria. PLoS One. 2011;6(8):e23684.