KIRA-7

• CAT Number: I017148
• CAS Number: 1937235-76-1
• Molecular Formula: C27H23FN6O
• Molecular Weight: 466.51
• Purity: ≥95%
• Synonyms: 1-[4-[8-amino-3-(1-methylcyclopropyl)imidazo[1,5-a]pyrazin-1-yl]naphthalen-1-yl]-3-(3-fluorophenyl)urea
• InChI: InChI=1S/C27H23FN6O/c1-27(11-12-27)25-33-22(23-24(29)30-13-14-34(23)25)20-9-10-21(19-8-3-2-7-18(19)20)32-26(35)31-17-6-4-5-16(28)15-17/h2-10,13-15H,11-12H2,1H3,(H2,29,30)(H2,31,32,35)
• InChIKey: BMEJPYIGRYVVEF-UHFFFAOYSA-N
• SMILES: CC1(CC1)C2=NC(=C3N2C=CN=C3N)C4=CC=C(C5=CC=CC=C54)NC(=O)NC6=CC(=CC=C6)F

KIRA-7(CAT: I017148) is an imidazopyrazine compound that binds the IRE1α kinase domain and allosterically inhibits its RNase activity (IC₅₀ = 110 nM). By suppressing IRE1α-mediated signaling, KIRA-7 effectively reduces XBP1 splicing and downstream unfolded protein response (UPR) activation. In alveolar epithelial MLE12 cells, it inhibits XBP1 splicing, while in C57BL/6 mice (5 mg/kg, i.p., 14 days), KIRA-7 significantly decreases spliced XBP1, ATF4, BiP, and CHOP levels after bleomycin exposure. Additionally, it lowers expression of fibrosis-associated genes, including collagen 1A1 and fibronectin, demonstrating strong anti-fibrotic potential. KIRA-7 is a valuable probe for studying ER stress, UPR signaling, and fibrosis.