KIF18A-IN-1

• CAT Number: I045190
• CAS Number: 2600559-12-2
• Molecular Formula: C28H40N4O5S2
• Molecular Weight: 576.77
• Purity: ≥95%
• Synonyms: 2-(6-azaspiro[2.5]octan-6-yl)-4-(tert-butylsulfamoyl)-N-[3-(tert-butylsulfamoyl)phenyl]benzamide
• InChI: InChI=1S/C28H40N4O5S2/c1-26(2,3)30-38(34,35)21-9-7-8-20(18-21)29-25(33)23-11-10-22(39(36,37)31-27(4,5)6)19-24(23)32-16-14-28(12-13-28)15-17-32/h7-11,18-19,30-31H,12-17H2,1-6H3,(H,29,33)
• InChIKey: XQJSQKALBZNWEV-UHFFFAOYSA-N
• SMILES: CC(C)(C)NS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)N3CCC4(CC4)CC3

KIF18A-IN-1（Cat No.:I045190）is a potent, selective inhibitor of kinesin family member 18A (KIF18A), a mitotic motor protein essential for chromosome alignment and spindle dynamics during cell division. By blocking KIF18A activity, it disrupts proper chromosome congression, leading to mitotic arrest and apoptosis in proliferating cells. KIF18A-IN-1 shows strong anti-proliferative effects in cancer cells dependent on KIF18A function, particularly those with chromosomal instability. It is a valuable research tool for studying mitotic regulation, spindle mechanics, and cancer cell vulnerability, with potential for developing targeted anti-mitotic cancer therapies.