For research use only. Not for therapeutic Use.
Ki16198（Cat No.:I006747）is a potent and selective antagonist of the prostaglandin E2 receptor subtype EP4, a G protein–coupled receptor involved in inflammation, immune modulation, and tumor progression. By blocking EP4-mediated signaling, Ki16198 suppresses downstream cAMP production and reduces pro-inflammatory and pro-tumorigenic responses. Preclinical studies highlight its therapeutic potential in cancer, autoimmune diseases, and inflammatory disorders. As a research tool, Ki16198 is widely applied to dissect prostaglandin signaling pathways, immune regulation, and the role of EP4 in disease progression, supporting the development of targeted anti-inflammatory and anticancer strategies.
| CAS Number | 355025-13-7 |
| Synonyms | methyl 3-[[4-[4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-methyl-1,2-oxazol-5-yl]phenyl]methylsulfanyl]propanoate |
| Molecular Formula | C24H25ClN2O5S |
| Purity | ≥95% |
| IUPAC Name | methyl 3-[[4-[4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-methyl-1,2-oxazol-5-yl]phenyl]methylsulfanyl]propanoate |
| InChI | InChI=1S/C24H25ClN2O5S/c1-15-22(26-24(29)31-16(2)19-6-4-5-7-20(19)25)23(32-27-15)18-10-8-17(9-11-18)14-33-13-12-21(28)30-3/h4-11,16H,12-14H2,1-3H3,(H,26,29) |
| InChIKey | HHVJBROTJWPHHX-UHFFFAOYSA-N |
| SMILES | CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
