For research use only. Not for therapeutic Use.
KH-CB20（Cat No.:I044335）is a selective and potent inhibitor of Exportin-1 (XPO1/CRM1), a nuclear export receptor involved in the transport of tumor suppressor proteins, growth regulators, and certain viral RNAs. By blocking XPO1 function, KH-CB20 causes the nuclear retention of key regulatory proteins like p53 and p21, promoting apoptosis and cell cycle arrest in cancer cells. It has shown promise in preclinical studies targeting hematologic malignancies and solid tumors. KH-CB20 is a valuable tool for studying nuclear-cytoplasmic transport mechanisms and exploring novel anti-cancer strategies focused on protein localization and signaling dynamics.
| CAS Number | 1354448-60-4 |
| Synonyms | ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methylindole-2-carboxylate |
| Molecular Formula | C15H13Cl2N3O2 |
| Purity | ≥95% |
| IUPAC Name | ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methylindole-2-carboxylate |
| InChI | InChI=1S/C15H13Cl2N3O2/c1-3-22-15(21)14-11(8(6-18)7-19)9-4-5-10(16)12(17)13(9)20(14)2/h4-6H,3,18H2,1-2H3/b8-6- |
| InChIKey | CXJCGSPAPOTTSF-VURMDHGXSA-N |
| SMILES | CCOC(=O)C1=C(C2=C(N1C)C(=C(C=C2)Cl)Cl)/C(=C\N)/C#N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
