For research use only. Not for therapeutic Use.
Ketorolac (Cat No.: I004750) is a non-selective inhibitor of cyclooxygenase (COX), with an IC50 of approximately 1.23 µM for human COX-1 and 3.50 µM for human COX-2. It is commonly employed as an anti-inflammatory analgesic, providing relief from pain and inflammation. Additionally, Ketorolac exhibits an anti-platelet aggregation effect, making it valuable in certain cardiovascular and thrombotic conditions. This dual action on COX enzymes and its anti-inflammatory properties contribute to its clinical utility. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.
| CAS Number | 74103-06-3 |
| Synonyms | 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid |
| Molecular Formula | C15H13NO3 |
| Purity | ≥95% |
| Target | Apoptosis |
| Solubility | DMSO 75 mg/mL; Water 75 mg/mL |
| Storage | 2-8°C |
| IUPAC Name | 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid |
| InChI | InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19) |
| InChIKey | OZWKMVRBQXNZKK-UHFFFAOYSA-N |
| SMILES | C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O |
| Reference | [1]. Jett, M.F., et al., Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. J Pharmacol Exp Ther, 1999. 288(3): p. 1288-97. [2]. Berg, J., et al., The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro. Inflamm Res, 1999. 48(7): p. 369-79. [3]. Chang, J.K., et al., Anti-inflammatory drugs suppress proliferation and induce apoptosis through altering expressions of cell cycle regulators and pro-apoptotic factors in cultured human osteoblasts. Toxicology, 2009. 258(2-3): p. 148-56.
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