KCC2 blocker 1

• CAT Number: I015579
• CAS Number: 1228439-36-8
• Molecular Formula: C22H25NO5S
• Molecular Weight: 415.50
• Purity: ≥95%
• Synonyms: benzyl 1-acetyl-2-[(4-methylsulfonylphenyl)methyl]pyrrolidine-2-carboxylate
• InChI: InChI=1S/C22H25NO5S/c1-17(24)23-14-6-13-22(23,21(25)28-16-19-7-4-3-5-8-19)15-18-9-11-20(12-10-18)29(2,26)27/h3-5,7-12H,6,13-16H2,1-2H3
• InChIKey: XFXZWVGQXNFWDE-UHFFFAOYSA-N
• SMILES: CC(=O)N1CCCC1(CC2=CC=C(C=C2)S(=O)(=O)C)C(=O)OCC3=CC=CC=C3

KCC2 Blocker 1（Cat No.:I015579）is a selective small-molecule inhibitor of the potassium-chloride cotransporter 2 (KCC2), a neuronal transporter essential for maintaining chloride homeostasis and inhibitory GABAergic signaling. By blocking KCC2, this compound disrupts chloride extrusion, leading to altered neuronal excitability and reduced inhibitory tone. It is primarily used as a research tool to study synaptic transmission, neuronal development, and pathophysiological conditions such as epilepsy, neuropathic pain, and neurodegenerative diseases. KCC2 Blocker 1 provides insights into chloride regulation and therapeutic strategies targeting excitatory–inhibitory balance in the brain.