KB02-COOH

• CAT Number: I045462
• CAS Number: 2375196-30-6
• Molecular Formula: C13H14ClNO4
• Molecular Weight: 283.71
• Purity: ≥95%
• Synonyms: 2-[[1-(2-chloroacetyl)-3,4-dihydro-2H-quinolin-6-yl]oxy]acetic acid
• InChI: InChI=1S/C13H14ClNO4/c14-7-12(16)15-5-1-2-9-6-10(3-4-11(9)15)19-8-13(17)18/h3-4,6H,1-2,5,7-8H2,(H,17,18)
• InChIKey: ZWIYQLVGARZWJJ-UHFFFAOYSA-N
• SMILES: C1CC2=C(C=CC(=C2)OCC(=O)O)N(C1)C(=O)CCl

KB02-COOH (Cat No.: I045462) is a chemical probe and reactive intermediate featuring a KB02 scaffold with a terminal carboxylic acid group for conjugation. It is commonly used in covalent ligand discovery and targeted protein degradation research, where the KB02 moiety can form covalent bonds with nucleophilic residues such as cysteines in target proteins. The carboxylic acid enables coupling to linkers, ligands, or reporter tags. KB02-COOH is particularly valuable in designing heterobifunctional molecules, including PROTACs and activity-based probes, for chemical biology and drug discovery applications.

Reference

[1]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.
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