KB-0742 dihydrochloride

• CAT Number: I044665
• CAS Number: 2416874-75-2
• Molecular Formula: C16H27Cl2N5
• Molecular Weight: 360.33
• Purity: ≥95%
• Synonyms: (1S,3S)-3-N-(5-pentan-3-ylpyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-diamine;dihydrochloride
• InChI: InChI=1S/C16H25N5.2ClH/c1-3-11(4-2)14-10-16(19-13-6-5-12(17)9-13)21-15(20-14)7-8-18-21;;/h7-8,10-13,19H,3-6,9,17H2,1-2H3;2*1H/t12-,13-;;/m0../s1
• InChIKey: OTUPXOLLHVLWQF-NJHZPMQHSA-N
• SMILES: CCC(CC)C1=NC2=CC=NN2C(=C1)N[C@H]3CC[C@@H](C3)N.Cl.Cl

KB-0742 dihydrochloride（Cat No.:I044665）is a selective, orally bioavailable inhibitor of cyclin-dependent kinase 9 (CDK9), a key regulator of transcriptional elongation via phosphorylation of RNA polymerase II. By targeting CDK9, KB-0742 suppresses the expression of oncogenes and short-lived transcripts critical for tumor cell survival, such as MYC and MCL-1. It shows potent antiproliferative activity in preclinical models of prostate cancer and hematologic malignancies. KB-0742 dihydrochloride is currently under investigation for its potential as a targeted cancer therapy and serves as a valuable tool in studying transcriptional addiction in cancer biology.