[K15,R16,L27]VIP(1-7)/GRF(8-27) acetate

• CAT Number: I040244
• Molecular Formula: C142H240N44O38.xC2H4O2
• Molecular Weight: 3171.70 (free base)
• Purity: ≥95%

[K15,R16,L27]VIP(1-7)/GRF(8-27) (acetate)(CAT: I040244) is a selective agonist for the VIP1 receptor, supplied as the acetate salt of the modified hybrid peptide [K15,R16,L27]VIP(1-7)/GRF(8-27) (HY-P4195). This compound exhibits potent binding affinity with IC₅₀ values of 2 nM for human VIP1, 1 nM for rat VIP1, and 30,000 nM for rat VIP2, demonstrating its high selectivity for VIP1 over VIP2 receptors. Derived from vasoactive intestinal polypeptide (VIP) and growth hormone-releasing factor (GRF), this peptide is ideal for investigating VIP1-mediated signaling, neuroendocrine regulation, and therapeutic targeting of VIP1 receptor pathways in inflammation, smooth muscle relaxation, and immunomodulation.