K-Ras ligand-Linker Conjugate 4

• CAT Number: I016930
• CAS Number: 2378261-83-5
• Molecular Formula: C35H51N7O8
• Molecular Weight: 697.82
• Purity: ≥95%
• Synonyms: benzyl (2S)-2-(cyanomethyl)-4-[2-[[(2S,4R)-4-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]-1-methylpyrrolidin-2-yl]methoxy]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]piperazine-1-carboxylate
• InChI: InChI=1S/C35H51N7O8/c1-40-24-30(48-20-19-47-18-17-46-16-15-45-14-13-43)21-29(40)26-49-34-38-32-22-37-10-8-31(32)33(39-34)41-11-12-42(28(23-41)7-9-36)35(44)50-25-27-5-3-2-4-6-27/h2-6,28-30,37,43H,7-8,10-26H2,1H3/t28-,29-,30+/m0/s1
• InChIKey: GUKYSZDGLMYSDL-OIFRRMEBSA-N
• SMILES: CN1CC(CC1COC2=NC3=C(CCNC3)C(=N2)N4CCN(C(C4)CC#N)C(=O)OCC5=CC=CC=C5)OCCOCCOCCOCCO

K-Ras ligand-Linker Conjugate 4(CAT: I016930) is a synthetic intermediate designed for the development of targeted protein degraders and covalent inhibitors directed against oncogenic K-Ras. It incorporates a validated K-Ras–binding ligand tethered to a chemical linker, enabling conjugation to E3 ligase recruiters or other functional groups for PROTAC construction or molecular probe development. The linker provides appropriate flexibility and solubility, ensuring efficient coupling and favorable pharmacological properties. As part of a modular design, K-Ras ligand-Linker Conjugate 4 is a valuable building block for oncology research, facilitating the exploration of RAS-driven signaling pathways and therapeutic strategies against RAS-mutant cancers.