K-Ras G12C-IN-4

• CAT Number: I017826
• CAS Number: 2376328-55-9
• Molecular Formula: C31H33ClN4O4
• Molecular Weight: 561.07
• Purity: ≥95%
• Synonyms: 2-[5-chloro-2-cyclopropyl-3-(5-methoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-7-methylindol-1-yl]-N-(1-prop-2-enoylazetidin-3-yl)acetamide
• InChI: InChI=1S/C31H33ClN4O4/c1-4-27(38)35-15-22(16-35)33-26(37)17-36-29-18(2)12-21(32)13-24(29)28(30(36)19-8-9-19)31(39)34-11-10-23-20(14-34)6-5-7-25(23)40-3/h4-7,12-13,19,22H,1,8-11,14-17H2,2-3H3,(H,33,37)
• InChIKey: JESBUJUEMLEHDQ-UHFFFAOYSA-N
• SMILES: CC1=CC(=CC2=C1N(C(=C2C(=O)N3CCC4=C(C3)C=CC=C4OC)C5CC5)CC(=O)NC6CN(C6)C(=O)C=C)Cl

K-Ras G12C-IN-4（Cat No.:I017826）is a covalent small-molecule inhibitor designed to selectively target the K-Ras G12C mutant, a common oncogenic driver in non-small cell lung cancer (NSCLC) and other solid tumors. It binds irreversibly to the mutant cysteine at position 12, locking K-Ras in its inactive GDP-bound state and preventing downstream MAPK/ERK signaling. This blockade suppresses tumor cell proliferation and survival, making it a promising therapeutic lead. K-Ras G12C-IN-4 is widely used in cancer research to investigate precision medicine approaches for Ras-driven malignancies.