K-975

• CAT Number: I029960
• CAS Number: 2563855-03-6
• Molecular Formula: C16H14ClNO2
• Molecular Weight: 287.74
• Purity: ≥95%
• Synonyms: N-[3-(4-chlorophenoxy)-4-methylphenyl]prop-2-enamide
• InChI: InChI=1S/C16H14ClNO2/c1-3-16(19)18-13-7-4-11(2)15(10-13)20-14-8-5-12(17)6-9-14/h3-10H,1H2,2H3,(H,18,19)
• InChIKey: KPXAHQSIROUBPH-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)NC(=O)C=C)OC2=CC=C(C=C2)Cl

K-975 （Cat No.:I029960）is a potent and selective inhibitor of the transcription factor TEAD, which is a key component of the Hippo signaling pathway involved in cell proliferation, survival, and organ size regulation. By disrupting TEAD’s interaction with its coactivator YAP/TAZ, K-975 effectively suppresses oncogenic transcriptional programs in YAP/TAZ-driven cancers. It exhibits strong activity in preclinical cancer models, particularly in mesothelioma and other solid tumors with Hippo pathway alterations. K-975 is a promising therapeutic candidate for targeting cancers driven by aberrant Hippo-YAP signaling and is used in mechanistic and translational oncology research.