JWH 251 4-methylphenyl isomer

• CAT Number: R067475
• CAS Number: 864445-41-0
• Molecular Formula: C22H25NO
• Molecular Weight: 319.45
• Purity: ≥95%
• Synonyms: JWH 251 4-methyl isomer
• Storage: -20°C
• IUPAC Name: 2-(4-methylphenyl)-1-(1-pentylindol-3-yl)ethanone
• InChI: InChI=1S/C22H25NO/c1-3-4-7-14-23-16-20(19-8-5-6-9-21(19)23)22(24)15-18-12-10-17(2)11-13-18/h5-6,8-13,16H,3-4,7,14-15H2,1-2H3
• InChIKey: GSVYYNBRAJBCQS-UHFFFAOYSA-N
• SMILES: CCCCCN1C=C(C2=CC=CC=C21)C(=O)CC3=CC=C(C=C3)C

The 4-methylphenyl isomer of JWH-251 is a synthetic cannabinoid belonging to the naphthoylindole family, structurally related to other JWH compounds. It features a 4-methyl substitution on the phenyl ring, which can influence binding affinity and selectivity for cannabinoid receptors, particularly CB1. This isomer is investigated for its pharmacological properties, including potential psychoactive and analgesic effects. Like other synthetic cannabinoids, it may act as a potent agonist at cannabinoid receptors, though its safety profile is not well-established. It is primarily used in research and is not approved for medical or recreational use.

Reference

1.Huffman, J.W.,Szklennik, P.V.,Almond, A., et al. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorganic & Medicinal Chemistry Letters 15, 4110-4113 (2005).