For research use only. Not for therapeutic Use.
JW480（Cat No.:I010934）is a potent and selective irreversible inhibitor of the serine hydrolase ABHD6 (α/β-hydrolase domain-containing 6), an enzyme involved in the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). By inhibiting ABHD6, JW480 elevates 2-AG levels, enhancing cannabinoid receptor signaling, particularly through CB1 and CB2 receptors. It is widely used in neurobiology and metabolic research to investigate endocannabinoid system modulation, neuroinflammation, and energy homeostasis. JW480 provides a valuable tool for dissecting the role of ABHD6 in physiological and pathological processes and for exploring potential therapeutic strategies targeting endocannabinoid metabolism.
| CAS Number | 1354359-53-7 |
| Synonyms | (2-propan-2-ylphenyl) N-(2-naphthalen-2-ylethyl)carbamate |
| Molecular Formula | C22H23NO2 |
| Purity | ≥95% |
| IUPAC Name | (2-propan-2-ylphenyl) N-(2-naphthalen-2-ylethyl)carbamate |
| InChI | InChI=1S/C22H23NO2/c1-16(2)20-9-5-6-10-21(20)25-22(24)23-14-13-17-11-12-18-7-3-4-8-19(18)15-17/h3-12,15-16H,13-14H2,1-2H3,(H,23,24) |
| InChIKey | PCNJGBMWAZRVEA-UHFFFAOYSA-N |
| SMILES | CC(C)C1=CC=CC=C1OC(=O)NCCC2=CC3=CC=CC=C3C=C2 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
