JNJ-54717793

• CAT Number: I029836
• CAS Number: 1628843-99-1
• Molecular Formula: C22H18F4N6O
• Molecular Weight: 458.41
• Purity: ≥95%
• Synonyms: (3-fluoro-2-pyrimidin-2-ylphenyl)-[(2R)-2-[[5-(trifluoromethyl)pyrazin-2-yl]amino]-7-azabicyclo[2.2.1]heptan-7-yl]methanone
• InChI: InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31)/t12?,15-,16?/m1/s1
• InChIKey: NWUAUSABGZEYEW-DSSZZKGTSA-N
• SMILES: C1CC2C(CC1N2C(=O)C3=C(C(=CC=C3)F)C4=NC=CC=N4)NC5=NC=C(N=C5)C(F)(F)F

JNJ-54717793 (Cat No.: I029836) is a selective antagonist of the orexin-1 receptor (OX1R), a receptor involved in regulating arousal, stress response, and reward pathways. By specifically blocking OX1R without affecting orexin-2 receptors, JNJ-54717793 offers a targeted approach for modulating neuropsychiatric conditions such as anxiety, addiction, and stress-related disorders. It has demonstrated anxiolytic and anti-addictive properties in preclinical studies. JNJ-54717793 is a valuable tool for exploring the role of the orexin system in central nervous system function and therapeutic intervention.

Reference

[1]. Préville C, et al. Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793. ACS Med Chem Lett. 2020;11(10):2002-2009. Published 2020 Apr 27.
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[2]. Bonaventure P, et al. Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation. Front Pharmacol. 2017;8:357. Published 2017 Jun 9.
[Content Brief]