For research use only. Not for therapeutic Use.
JNJ-1661010 (CAT: R061410 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC₅₀ values of 34 nM (rat) and 33 nM (human). By inhibiting FAAH, it elevates endogenous endocannabinoid levels, producing analgesic and anti-inflammatory effects. JNJ-1661010 readily crosses the blood–brain barrier, supporting its role as a central nervous system–active compound. In the carrageenan-induced inflammatory rat model, intraperitoneal administration (50 mg/kg) significantly reduces thermal hyperalgesia. Pharmacokinetic studies in rats show a half-life of 35 minutes, clearance of 0.032 mL/min/kg, and a Cmax of 1.58 μM. JNJ-1661010 is a valuable tool for pain, inflammation, and endocannabinoid research.
| CAS Number | 681136-29-8 |
| Synonyms | N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide |
| Molecular Formula | C19H19N5OS |
| Purity | ≥95% |
| IUPAC Name | N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide |
| InChI | InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25) |
| InChIKey | BHBOSTKQCZEAJM-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1C2=NC(=NS2)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
