JNJ-10198409

• CAT Number: I011729
• CAS Number: 627518-40-5
• Molecular Formula: C18H16FN3O2
• Molecular Weight: 325.34
• Purity: ≥95%
• Synonyms: N-(3-fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
• IUPAC Name: N-(3-fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[2,1-d]pyrazol-3-amine
• InChI: InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)
• InChIKey: ZDNURMVOKAERHZ-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2C(=C1)CC3=C2NN=C3NC4=CC(=CC=C4)F)OC

JNJ-10198409（Cat No.:I011729）is a selective small-molecule inhibitor of platelet-derived growth factor receptor β (PDGFRβ), a receptor tyrosine kinase implicated in tumor growth, angiogenesis, and fibrotic diseases. By blocking PDGFRβ signaling, JNJ-10198409 suppresses downstream pathways that promote cell proliferation, survival, and migration. It has been studied in preclinical cancer research, particularly for glioblastoma, sarcomas, and other PDGFR-driven malignancies, as well as fibrotic disorders. JNJ-10198409 serves as a pharmacological tool to investigate PDGFRβ biology and assess therapeutic strategies targeting abnormal receptor tyrosine kinase activity in oncology and fibrosis.