For research use only. Not for therapeutic Use.
JMV 449 acetate（Cat No.:I044322）is a synthetic peptide analog of neurotensin, a neuropeptide involved in modulating dopamine signaling, pain perception, and gastrointestinal activity. JMV 449 is designed to mimic and enhance neurotensin’s biological activity while improving metabolic stability and receptor selectivity. It acts primarily on neurotensin receptor 1 (NTSR1) and is used in research to study neurotensin-mediated signaling in the central nervous system and peripheral tissues. The acetate form enhances the peptide’s solubility and stability. JMV 449 is valuable in neuroscience, cancer, and metabolic disorder studies involving neurotensin pathways.
| CAS Number | 141863-45-8 |
| Synonyms | acetic acid;(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2,6-diaminohexyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid |
| Molecular Formula | C40H70N8O9 |
| Purity | ≥95% |
| IUPAC Name | acetic acid;(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2,6-diaminohexyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid |
| InChI | InChI=1S/C38H66N8O7.C2H4O2/c1-5-25(4)33(36(50)44-31(38(52)53)21-24(2)3)45-34(48)30(22-26-14-16-28(47)17-15-26)43-35(49)32-13-10-20-46(32)37(51)29(12-7-9-19-40)42-23-27(41)11-6-8-18-39;1-2(3)4/h14-17,24-25,27,29-33,42,47H,5-13,18-23,39-41H2,1-4H3,(H,43,49)(H,44,50)(H,45,48)(H,52,53);1H3,(H,3,4)/t25-,27-,29-,30-,31-,32-,33-;/m0./s1 |
| InChIKey | JWAZBOKEQASLBT-ULBMXYNPSA-N |
| SMILES | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC[C@H](CCCCN)N.CC(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
