For research use only. Not for therapeutic Use.
JMS-053（Cat No.:I029802）is a potent, selective, and reversible small-molecule inhibitor of protein tyrosine phosphatase 4A3 (PTP4A3 or PRL-3), an oncogenic phosphatase implicated in tumor progression, metastasis, and angiogenesis. By inhibiting PRL-3 activity, JMS-053 suppresses cancer cell migration and invasion, making it a valuable tool for studying tumor metastasis mechanisms and PTP4A3-targeted therapy development. It has shown promising activity in preclinical cancer models, particularly in colorectal, ovarian, and hematologic malignancies. JMS-053 is used to explore phosphatase biology, signaling regulation, and the therapeutic potential of targeting PRL family phosphatases in aggressive cancers.
| CAS Number | 1954650-11-3 |
| Synonyms | 7-imino-2-phenylthieno[3,2-c]pyridine-4,6-dione |
| Molecular Formula | C13H8N2O2S |
| Purity | ≥95% |
| IUPAC Name | 7-imino-2-phenylthieno[3,2-c]pyridine-4,6-dione |
| InChI | InChI=1S/C13H8N2O2S/c14-10-11-8(12(16)15-13(10)17)6-9(18-11)7-4-2-1-3-5-7/h1-6,14H,(H,15,16,17) |
| InChIKey | CQHAROORCYWRRH-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=CC3=C(S2)C(=N)C(=O)NC3=O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
