JKE‑1716（Cat No.:I044695）is a potent, selective inhibitor of glutathione peroxidase 4 (GPX4), leveraging a nitrolic acid scaffold to covalently target the enzyme’s active site. By inhibiting GPX4, it disrupts cellular redox balance and induces iron-dependent lipid peroxidation, triggering ferroptosis in susceptible cancer cells. In vitro, JKE‑1716 reduces viability of LOX‑IMVI melanoma cells at low nanomolar concentrations (0–100 nM; 72 h), an effect reversible by the ferroptosis inhibitor ferrostatin‑1 . It serves as a valuable research tool for probing ferroptotic mechanisms and exploring GPX4’s therapeutic potential.