For research use only. Not for therapeutic Use.
JHU395（Cat No.:I017823）is a brain-penetrant, selective inhibitor of glutamine metabolism that targets glutaminase activity, disrupting glutamine utilization in cancer cells. By blocking this pathway, JHU395 reduces production of glutamate and downstream metabolites essential for tumor growth and survival. Its ability to cross the blood–brain barrier makes it especially valuable for studying glioblastoma and other brain cancers. JHU395 is also a tool for exploring metabolic vulnerabilities in oncology, highlighting glutamine addiction as a therapeutic target. Its potency and specificity support translational research into cancer metabolism.
| CAS Number | 2079938-92-2 |
| Synonyms | propan-2-yl (2S)-6-diazo-2-[[2,2-dimethylpropanoyloxy(phenyl)methoxy]carbonylamino]-5-oxohexanoate |
| Molecular Formula | C22H29N3O7 |
| Purity | ≥95% |
| IUPAC Name | propan-2-yl (2S)-6-diazo-2-[[2,2-dimethylpropanoyloxy(phenyl)methoxy]carbonylamino]-5-oxohexanoate |
| InChI | InChI=1S/C22H29N3O7/c1-14(2)30-18(27)17(12-11-16(26)13-24-23)25-21(29)32-19(15-9-7-6-8-10-15)31-20(28)22(3,4)5/h6-10,13-14,17,19H,11-12H2,1-5H3,(H,25,29)/t17-,19?/m0/s1 |
| InChIKey | QQIBFRQTTLIECS-KKFHFHRHSA-N |
| SMILES | CC(C)OC(=O)[C@H](CCC(=O)C=[N+]=[N-])NC(=O)OC(C1=CC=CC=C1)OC(=O)C(C)(C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
