For research use only. Not for therapeutic Use.
JHU37152 (Cat No.: I029781) is a potent, selective positive allosteric modulator (PAM) of the muscarinic acetylcholine receptor subtype M1 (M1 mAChR), which plays a key role in cognitive processing, memory, and synaptic plasticity. By enhancing receptor response to endogenous acetylcholine without directly activating the receptor, JHU37152 improves signal specificity and reduces side effects associated with direct agonists. It is used in neuroscience research to investigate M1 receptor function and as a potential therapeutic lead for cognitive deficits in Alzheimer’s disease, schizophrenia, and other neuropsychiatric disorders.
| CAS Number | 2369979-67-7 |
| Synonyms | 3-chloro-6-(4-ethylpiperazin-1-yl)-7-fluoro-11H-benzo[b][1,4]benzodiazepine |
| Molecular Formula | C19H20ClFN4 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H20ClFN4/c1-2-24-8-10-25(11-9-24)19-18-14(21)4-3-5-16(18)22-15-7-6-13(20)12-17(15)23-19/h3-7,12,22H,2,8-11H2,1H3 |
| InChIKey | NZMZJNNWMSYDNX-UHFFFAOYSA-N |
| SMILES | CCN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=C2C(=CC=C4)F |
| Reference | [1]. Bonaventura J, et, al. High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat Commun. 2019 Oct 11;10(1):4627. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
