For research use only. Not for therapeutic Use.
JH295（Cat No.:I007411）is a selective, activity-based probe designed to target and covalently modify caspase-6, a cysteine protease involved in programmed cell death and neurodegenerative disease pathways. By irreversibly binding to the active enzyme, JH295 enables precise detection, quantification, and functional characterization of caspase-6 activity in cellular and biochemical systems. This compound is particularly useful for studying apoptosis, axonal degeneration, and caspase-mediated mechanisms in disorders such as Alzheimer’s and Huntington’s disease. JH295 serves as a powerful research tool for validating caspase-6 as a therapeutic target in neurobiology.
| CAS Number | 1311143-71-1 |
| Synonyms | N-[(3Z)-3-[(2-ethyl-5-methyl-1H-imidazol-4-yl)methylidene]-2-oxo-1H-indol-5-yl]prop-2-ynamide |
| Molecular Formula | C18H16N4O2 |
| Purity | ≥95% |
| IUPAC Name | N-[(3Z)-3-[(2-ethyl-5-methyl-1H-imidazol-4-yl)methylidene]-2-oxo-1H-indol-5-yl]prop-2-ynamide |
| InChI | InChI=1S/C18H16N4O2/c1-4-16-19-10(3)15(21-16)9-13-12-8-11(20-17(23)5-2)6-7-14(12)22-18(13)24/h2,6-9H,4H2,1,3H3,(H,19,21)(H,20,23)(H,22,24)/b13-9- |
| InChIKey | ORKOHXAJFGRZCL-LCYFTJDESA-N |
| SMILES | CCC1=NC(=C(N1)C)/C=C\2/C3=C(C=CC(=C3)NC(=O)C#C)NC2=O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
