JH-LPH-33

• CAT Number: I016923
• CAS Number: 2414590-04-6
• Molecular Formula: C21H21ClF3N3O3S
• Molecular Weight: 487.92
• Purity: ≥95%
• Synonyms: 1-[5-[4-[3-chloro-5-(trifluoromethyl)phenyl]piperazin-1-yl]sulfonyl-2,3-dihydroindol-1-yl]ethanone
• InChI: InChI=1S/C21H21ClF3N3O3S/c1-14(29)28-5-4-15-10-19(2-3-20(15)28)32(30,31)27-8-6-26(7-9-27)18-12-16(21(23,24)25)11-17(22)13-18/h2-3,10-13H,4-9H2,1H3
• InChIKey: PDEIRNVIXFZSSJ-UHFFFAOYSA-N
• SMILES: CC(=O)N1CCC2=C1C=CC(=C2)S(=O)(=O)N3CCN(CC3)C4=CC(=CC(=C4)C(F)(F)F)Cl

JH-LPH-33(CAT: I016923) is a sulfonyl piperazine analog and a potent inhibitor of UDP-2,3-diacylglucosamine pyrophosphate hydrolase (LpxH), a key enzyme in lipid A biosynthesis. It exhibits remarkable antibacterial activity, with IC₅₀ values of 0.026 μM against Klebsiella pneumoniae LpxH and 0.046 μM against Escherichia coli LpxH. JH-LPH-33 demonstrates strong growth inhibition of K. pneumoniae with a MIC of 0.66 μg/mL, while showing limited efficacy against E. coli (MIC >64 μg/mL). By targeting lipid A biosynthesis, JH-LPH-33 is a valuable tool for antibacterial drug discovery and the development of therapies against multidrug-resistant Gram-negative pathogens.