JGB1741

• CAT Number: I011799
• CAS Number: 1256375-38-8
• Molecular Formula: C27H24N2O2S
• Molecular Weight: 440.56
• Purity: ≥95%
• Synonyms: N-benzyl-2-[(E)-(2-hydroxynaphthalen-1-yl)methylideneamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
• InChI: InChI=1S/C27H24N2O2S/c30-23-15-14-19-10-4-5-11-20(19)22(23)17-29-27-25(21-12-6-7-13-24(21)32-27)26(31)28-16-18-8-2-1-3-9-18/h1-5,8-11,14-15,17,30H,6-7,12-13,16H2,(H,28,31)/b29-17+
• InChIKey: CRTIXRJWHKMWCH-STBIYBPSSA-N
• SMILES: C1CCC2=C(C1)C(=C(S2)N=CC3=C(C=CC4=CC=CC=C43)O)C(=O)NCC5=CC=CC=C5

JGB1741 (Cat No.: I011799) is a synthetic small-molecule compound investigated for its potential role as a research tool in biomedical studies. It has been explored for modulating cellular signaling pathways and interactions relevant to disease progression, making it useful in preclinical drug discovery. Researchers utilize JGB1741 to study structure–activity relationships, target engagement, and pharmacological effects in experimental models. While not approved for therapeutic use, JGB1741 provides insight into molecular mechanisms and supports the identification of novel strategies for future therapeutic development.

Reference

[1]. Arunasree M Kalle, et al. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. Biochem Biophys Res Commun. 2010 Oct 8;401(1):13-9.
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