For research use only. Not for therapeutic Use.
JG-2016(CAT: I040587) is a selective small-molecule inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A), designed to modulate epigenetic regulation in cancer and stem cell biology. By inhibiting LSD1’s histone demethylase activity, JG-2016 alters chromatin structure and gene expression programs associated with proliferation, differentiation, and oncogenesis. It has shown efficacy in preclinical models of acute myeloid leukemia (AML) and other LSD1-dependent malignancies. JG-2016 is a valuable tool for investigating the role of histone methylation dynamics in epigenetic control and therapeutic targeting.
| CAS Number | 2887480-87-5 |
| Synonyms | 7-chloro-8-ethyl-10-[2-(2-methylpropoxy)ethyl]benzo[g]pteridine-2,4-dione |
| Molecular Formula | C18H21ClN4O3 |
| Purity | ≥95% |
| IUPAC Name | 7-chloro-8-ethyl-10-[2-(2-methylpropoxy)ethyl]benzo[g]pteridine-2,4-dione |
| InChI | InChI=1S/C18H21ClN4O3/c1-4-11-7-14-13(8-12(11)19)20-15-16(21-18(25)22-17(15)24)23(14)5-6-26-9-10(2)3/h7-8,10H,4-6,9H2,1-3H3,(H,22,24,25) |
| InChIKey | IOHJEWFKBRNJIO-UHFFFAOYSA-N |
| SMILES | CCC1=CC2=C(C=C1Cl)N=C3C(=O)NC(=O)N=C3N2CCOCC(C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
