JC-171

• CAT Number: I015039
• CAS Number: 2112809-98-8
• Molecular Formula: C16H17ClN2O5S
• Molecular Weight: 384.83
• Purity: ≥95%
• Synonyms: 5-chloro-N-[2-[4-(hydroxysulfamoyl)phenyl]ethyl]-2-methoxybenzamide
• InChI: InChI=1S/C16H17ClN2O5S/c1-24-15-7-4-12(17)10-14(15)16(20)18-9-8-11-2-5-13(6-3-11)25(22,23)19-21/h2-7,10,19,21H,8-9H2,1H3,(H,18,20)
• InChIKey: KQRQPMUPYDOTCA-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NO

JC-171（Cat No.:I015039）is a selective small-molecule inhibitor of the NLRP3 inflammasome, a multiprotein complex that regulates caspase-1 activation and the release of pro-inflammatory cytokines IL-1β and IL-18. By blocking NLRP3 activation, JC-171 effectively reduces inflammatory signaling and pyroptotic cell death. This compound is widely applied in immunology and inflammation research, particularly in studying autoimmune diseases, metabolic disorders, and neurodegenerative conditions where aberrant NLRP3 activity contributes to pathology. JC-171 serves as a valuable tool for probing inflammasome biology and advancing therapeutic strategies targeting chronic inflammatory diseases.