Jasplakinolide

  • CAT Number: R016194
  • CAS Number: 102396-24-7
  • Molecular Formula: C36H45BrN4O6
  • Molecular Weight: 709.7
  • Purity: ≥95%
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Jasplakinolide(Cat No.:R016194) is a powerful compound derived from marine sponges that induce actin polymerization and stabilize existing actin filaments. It competes with phalloidin for binding to F-actin, with a Kd value of 15nM. This natural cyclic peptide exhibits antifungal and antitumor properties. Jasplakinolide’s ability to modulate actin dynamics makes it a valuable tool in cell biology research, particularly in studying cytoskeletal organization and cell motility. It’s unique properties and biological activities make it a promising candidate for therapeutic applications in antifungal and antitumor treatments.

Catalog Number R016194
CAS Number 102396-24-7
Synonyms

NSC 613009; [2S-[1(S*),2R*,4E,6S*,8R*]]-N-[2-Bromo-N-[N-(8-hydroxy-2,4,6-trimethyl-1-oxo-4-nonenyl)-L-alanyl]-N-methyl-D-tryptophyl]-3-(4-hydroxyphenyl)-β-alanine ρ-Lactone; 1-Oxa-5,8,11-triazacyclononadecane β-alanine deriv.; (+)-Jasplakinolide; Jas

Molecular Formula

C36H45BrN4O6

Purity 95%
Target Actin
Solubility Soluble in DMSO > 10 mM
Storage Store at -20°C
IUPAC Name (4R,7R,10S,13S,15E,17R,19S)-7-[(2-bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone
InChI InChI=1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22-,23-,24-,30+,31+/m0/s1
InChIKey GQWYWHOHRVVHAP-DHKPLNAMSA-N
SMILES CC1CC(OC(=O)CC(NC(=O)C(N(C(=O)C(NC(=O)C(CC(=C1)C)C)C)C)CC2=C(NC3=CC=CC=C32)Br)C4=CC=C(C=C4)O)C

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