For research use only. Not for therapeutic Use.
JAK-IN-5 hydrochloride（Cat No.:I045878）is a potent small-molecule inhibitor of Janus kinases (JAKs), critical mediators of cytokine signaling through the JAK/STAT pathway. By blocking JAK activity, it disrupts downstream STAT phosphorylation, thereby reducing inflammatory and immune responses. This compound is widely applied in research focused on autoimmune diseases, inflammation, and hematological malignancies, where aberrant JAK signaling drives disease progression. Supplied as a hydrochloride salt for stability and solubility, JAK-IN-5 hydrochloride is a valuable tool for dissecting cytokine-mediated pathways and evaluating therapeutic strategies targeting JAK-driven disorders.
| CAS Number | 2751323-21-2 |
| Synonyms | 5-ethyl-2-fluoro-4-[3-[5-(1-methylpiperidin-4-yl)-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-2-yl]-1H-indazol-6-yl]phenol;hydrochloride |
| Molecular Formula | C27H32ClFN6O |
| Purity | ≥95% |
| IUPAC Name | 5-ethyl-2-fluoro-4-[3-[5-(1-methylpiperidin-4-yl)-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-2-yl]-1H-indazol-6-yl]phenol;hydrochloride |
| InChI | InChI=1S/C27H31FN6O.ClH/c1-3-16-13-25(35)21(28)14-20(16)17-4-5-19-23(12-17)31-32-26(19)27-29-22-8-11-34(15-24(22)30-27)18-6-9-33(2)10-7-18;/h4-5,12-14,18,35H,3,6-11,15H2,1-2H3,(H,29,30)(H,31,32);1H |
| InChIKey | IQLPCWWFLJIQJF-UHFFFAOYSA-N |
| SMILES | CCC1=CC(=C(C=C1C2=CC3=C(C=C2)C(=NN3)C4=NC5=C(N4)CN(CC5)C6CCN(CC6)C)F)O.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
