For research use only. Not for therapeutic Use.
Izilendustat（Cat No.:I045039）is an investigational small-molecule inhibitor of prolyl hydroxylase domain (PHD) enzymes, developed to treat anemia, particularly anemia associated with chronic kidney disease (CKD). By inhibiting PHD enzymes, izilendustat stabilizes hypoxia-inducible factor (HIF), promoting endogenous erythropoietin (EPO) production and enhancing iron metabolism and red blood cell formation. This oral HIF-PHD inhibitor mimics the body’s natural response to hypoxia, offering a potential alternative to injectable erythropoiesis-stimulating agents. Izilendustat is currently under clinical evaluation and holds promise for improving anemia management with a more physiologically regulated mechanism of action.
| CAS Number | 1303512-02-8 |
| Synonyms | tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate |
| Molecular Formula | C22H28ClN3O4 |
| Purity | ≥95% |
| IUPAC Name | tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate |
| InChI | InChI=1S/C22H28ClN3O4/c1-22(2,3)30-21(29)25-12-10-24(11-13-25)15-17-8-9-26(20(28)19(17)27)14-16-4-6-18(23)7-5-16/h4-9,27H,10-15H2,1-3H3 |
| InChIKey | UPJZLOCUUOIMNC-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)N1CCN(CC1)CC2=C(C(=O)N(C=C2)CC3=CC=C(C=C3)Cl)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
