For research use only. Not for therapeutic Use.
IWP-3（Cat No.:I011838）is a potent inhibitor of Wnt protein secretion, targeting the enzyme Porcupine (PORCN), which is essential for Wnt ligand palmitoylation and maturation. By blocking PORCN, IWP-3 effectively suppresses both canonical and non-canonical Wnt signaling pathways. It is widely used in developmental biology and cancer research to investigate the role of Wnt signaling in cell fate determination, proliferation, and differentiation. IWP-3 has been instrumental in studies involving stem cell maintenance, tissue regeneration, and tumor progression, offering insights into potential therapeutic targets for Wnt-driven diseases such as colorectal cancer and fibrosis.
| CAS Number | 687561-60-0 |
| Synonyms | 2-[[3-(4-fluorophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide |
| Molecular Formula | C22H17FN4O2S3 |
| Purity | ≥95% |
| IUPAC Name | 2-[[3-(4-fluorophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide |
| InChI | InChI=1S/C22H17FN4O2S3/c1-12-2-7-15-17(10-12)32-21(24-15)26-18(28)11-31-22-25-16-8-9-30-19(16)20(29)27(22)14-5-3-13(23)4-6-14/h2-7,10H,8-9,11H2,1H3,(H,24,26,28) |
| InChIKey | XVMHQSDMKWQNBK-UHFFFAOYSA-N |
| SMILES | CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=C(C=C5)F)SCC4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
