Ivaltinostat formic

• CAT Number: I045067
• Molecular Formula: C25H35N3O6
• Molecular Weight: 473.56
• Purity: ≥95%
• Synonyms: (E)-N-[3-(dimethylamino)propyl]-N’-hydroxy-2-(naphthalen-1-yloxymethyl)oct-2-enediamide;formic acid
• IUPAC Name: (E)-N-[3-(dimethylamino)propyl]-N'-hydroxy-2-(naphthalen-1-yloxymethyl)oct-2-enediamide;formic acid
• InChI: InChI=1S/C24H33N3O4.CH2O2/c1-27(2)17-9-16-25-24(29)20(11-4-3-5-15-23(28)26-30)18-31-22-14-8-12-19-10-6-7-13-21(19)22;2-1-3/h6-8,10-14,30H,3-5,9,15-18H2,1-2H3,(H,25,29)(H,26,28);1H,(H,2,3)/b20-11+
• InChIKey: VEXVTHBGCTTXEI-DOELHFPHSA-N
• SMILES: CN(C)CCCNC(=O)/C(=C/CCCCC(=O)NO)/COC1=CC=CC2=CC=CC=C21.C(=O)O

Ivaltinostat formic（Cat No.:I045067）is a formate salt of ivaltinostat (CG200745), a selective histone deacetylase (HDAC) inhibitor under investigation for cancer therapy. It targets class I and II HDACs, promoting histone acetylation, which leads to chromatin relaxation and reactivation of tumor suppressor genes. Ivaltinostat exhibits antiproliferative and pro-apoptotic effects in various malignancies, including pancreatic, lung, and hematologic cancers. The formate salt improves its solubility and pharmacokinetic properties for preclinical and clinical use. It is also being studied in combination with other chemotherapeutics to enhance antitumor efficacy and overcome resistance.