For research use only. Not for therapeutic Use.
Ivachtin (CAT: I011543) is a potent, reversible, and nonpeptidic caspase-3 inhibitor with an IC₅₀ of 23 nM. Unlike peptide-based inhibitors, Ivachtin acts in a noncompetitive manner and demonstrates modest selectivity over other caspase family members. In cellular models, Ivachtin (10–100 μM) exhibits protective effects against staurosporine-induced apoptosis in human Jurkat T cells, highlighting its role in apoptosis regulation. By selectively modulating caspase-3 activity, Ivachtin is a valuable pharmacological tool for studying apoptotic signaling pathways and exploring therapeutic strategies in cancer, neurodegeneration, and immune-related diseases where caspase-mediated cell death is critical.
| CAS Number | 745046-84-8 |
| Synonyms | 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate |
| Molecular Formula | C20H21N3O7S |
| Purity | ≥95% |
| IUPAC Name | 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate |
| InChI | InChI=1S/C20H21N3O7S/c1-12-17-18(20(26)23(19(17)25)7-10-30-13(2)24)15-11-14(3-4-16(15)21-12)31(27,28)22-5-8-29-9-6-22/h3-4,11H,5-10H2,1-2H3 |
| InChIKey | MWXJJTMEUGWKKY-UHFFFAOYSA-N |
| SMILES | CC1=C2C(=C3C=C(C=CC3=N1)S(=O)(=O)N4CCOCC4)C(=O)N(C2=O)CCOC(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
