IV-361

• CAT Number: I044457
• CAS Number: 2055741-39-2
• Molecular Formula: C23H32FN5O2Si
• Molecular Weight: 457.62
• Purity: ≥95%
• Synonyms: N-(5-fluoro-2-methylphenyl)-6,6-dimethyl-3-[(1-trimethylsilylcyclobutanecarbonyl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide
• InChI: InChI=1S/C23H32FN5O2Si/c1-14-8-9-15(24)12-17(14)25-21(31)29-13-16-18(22(29,2)3)27-28-19(16)26-20(30)23(10-7-11-23)32(4,5)6/h8-9,12H,7,10-11,13H2,1-6H3,(H,25,31)(H2,26,27,28,30)
• InChIKey: FYIUNJAFLWNBAI-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)F)NC(=O)N2CC3=C(C2(C)C)NN=C3NC(=O)C4(CCC4)[Si](C)(C)C

IV-361（Cat No.:I044457）is a selective, small-molecule inhibitor targeting interleukin-1 receptor-associated kinase 4 (IRAK4), a critical mediator of Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling pathways. By inhibiting IRAK4, IV-361 blocks the downstream activation of NF-κB and MAPK pathways, reducing the production of pro-inflammatory cytokines such as IL-6 and TNF-α. This compound is valuable in preclinical research on autoimmune and inflammatory diseases, including rheumatoid arthritis, lupus, and psoriasis. IV-361 supports the development of targeted therapies aimed at modulating innate immune responses and treating chronic inflammatory conditions.