For research use only. Not for therapeutic Use.
ITH12575（Cat No.:I007391）is a potent and selective inhibitor of the mitochondrial Na⁺/Ca²⁺ exchanger (mNCX), derived from CGP37157. It effectively reduces calcium efflux from mitochondria to the cytosol in HeLa cells, exhibiting an EC₅₀ of 0.69 μM . At higher concentrations, it also diminishes calcium influx through the CALHM1 channel, which plays a role in neuronal electrical activity . ITH12575 has demonstrated neuroprotective effects, safeguarding against glutamate-induced excitotoxicity in rat hippocampal slices and oxidative stress in neuroblastoma cells .
| CAS Number | 1802013-08-6 |
| Synonyms | 7-chloro-5-(2-propan-2-ylphenyl)-1,5-dihydro-4,1-benzothiazepin-2-one |
| Molecular Formula | C18H18ClNOS |
| Purity | ≥95% |
| IUPAC Name | 7-chloro-5-(2-propan-2-ylphenyl)-1,5-dihydro-4,1-benzothiazepin-2-one |
| InChI | InChI=1S/C18H18ClNOS/c1-11(2)13-5-3-4-6-14(13)18-15-9-12(19)7-8-16(15)20-17(21)10-22-18/h3-9,11,18H,10H2,1-2H3,(H,20,21) |
| InChIKey | RDMUJSJZBYAAEF-UHFFFAOYSA-N |
| SMILES | CC(C)C1=CC=CC=C1C2C3=C(C=CC(=C3)Cl)NC(=O)CS2 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
