For research use only. Not for therapeutic Use.
ITF 3756(CAT: I029649) is a potent and selective inhibitor of histone deacetylase 6 (HDAC6), designed to modulate immune and oncogenic signaling pathways. It effectively reduces the expression of PD-L1 on human monocytes and CD8⁺ T cells in vitro, thereby enhancing immune-mediated tumor suppression. ITF 3756 exhibits promising antitumor activity, making it a valuable tool for cancer immunotherapy research. Its selective HDAC6 inhibition supports the study of non-histone protein acetylation and its impact on immune regulation, cell migration, and tumor progression. Ideal for preclinical evaluation and mechanistic investigations, ITF 3756 is supplied in high purity for advanced biomedical research.
| CAS Number | 2247608-27-9 |
| Synonyms | N-hydroxy-4-[(5-thiophen-2-yltetrazol-1-yl)methyl]benzamide |
| Molecular Formula | C13H11N5O2S |
| Purity | ≥95% |
| IUPAC Name | N-hydroxy-4-[(5-thiophen-2-yltetrazol-1-yl)methyl]benzamide |
| InChI | InChI=1S/C13H11N5O2S/c19-13(15-20)10-5-3-9(4-6-10)8-18-12(14-16-17-18)11-2-1-7-21-11/h1-7,20H,8H2,(H,15,19) |
| InChIKey | UFUGFWWXDWPEQE-UHFFFAOYSA-N |
| SMILES | C1=CSC(=C1)C2=NN=NN2CC3=CC=C(C=C3)C(=O)NO |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
