Isoscabertopin

• CAT Number: R055688
• CAS Number: 439923-16-7
• Molecular Formula: C20H22O6
• Molecular Weight: 358.39
• Purity: ≥95%
• Synonyms: [(3S,4R,8R,9E,12S)-10-methyl-5-methylidene-6,14-dioxo-7,13-dioxatricyclo[10.2.1.04,8]pentadeca-1(15),9-dien-3-yl] (Z)-2-methylbut-2-enoate
• IUPAC Name: [(3S,4R,8R,9E,12R)-10-methyl-5-methylidene-6,14-dioxo-7,13-dioxatricyclo[10.2.1.04,8]pentadeca-1(15),9-dien-3-yl] (Z)-2-methylbut-2-enoate
• InChI: InChI=1S/C20H22O6/c1-5-11(3)18(21)25-16-9-13-8-14(24-20(13)23)6-10(2)7-15-17(16)12(4)19(22)26-15/h5,7-8,14-17H,4,6,9H2,1-3H3/b10-7+,11-5-/t14-,15-,16+,17+/m1/s1
• InChIKey: FTPHYXGWMIZVMP-GAFRNKKQSA-N
• SMILES: C/C=C(/C)\C(=O)O[C@H]1CC2=C[C@@H](C/C(=C/[C@@H]3[C@@H]1C(=C)C(=O)O3)/C)OC2=O

Isoscabertopin（Cat No.:R055688）is a sesquiterpene lactone isolated from medicinal plants such as Inula species, traditionally used in herbal remedies. Belonging to the germacranolide-type sesquiterpenes, it contains a reactive α-methylene-γ-lactone group that contributes to its biological activity. Isoscabertopin has been studied for anti-inflammatory, antimicrobial, and cytotoxic properties, with potential applications in cancer research. It is known to inhibit NF-κB signaling and modulate cellular redox balance, thereby regulating apoptosis and inflammatory responses. As a bioactive natural compound, isoscabertopin is important in phytochemistry and natural product–based drug discovery.