Isonipecotic Acid

• CAT Number: R019371
• CAS Number: 498-94-2
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.16
• Purity: ≥95%
• Synonyms: 4-Piperidinecarboxylic Acid; 4-Carboxypiperidine; Hexahydroisonicotinic Acid; NSC 61049; Isonipecotinic Acid
• Target: Neuronal Signaling
• Storage: -20°C
• IUPAC Name: piperidine-4-carboxylic acid
• InChI: InChI=1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9)
• InChIKey: SRJOCJYGOFTFLH-UHFFFAOYSA-N
• SMILES: C1CNCCC1C(=O)O

Isonipecotic Acid(CAT: R019371) is a piperidine-based amino acid derivative and a well-known GABA receptor agonist frequently employed in neuropharmacological research. Structurally related to γ-aminobutyric acid (GABA), it selectively interacts with GABAA_AA​ receptors, making it a valuable tool for studying inhibitory neurotransmission, ion channel modulation, and central nervous system function. Researchers utilize Isonipecotic Acid to investigate mechanisms underlying epilepsy, anxiety, sleep regulation, and neurodegenerative disorders, where GABAergic balance plays a central role. Its defined activity also supports structure–activity relationship (SAR) studies and drug discovery programs targeting neurological diseases, establishing it as an important reference compound in neuroscience research.