For research use only. Not for therapeutic Use.
Isofebrifugine(CAT: I016782) is a quinazolinone alkaloid and structural isomer of febrifugine, a bioactive compound originally isolated from Dichroa febrifuga. It is known for potent antimalarial and anti-inflammatory activities. Isofebrifugine has been reported to inhibit Plasmodium growth by interfering with parasite metabolism and nucleic acid synthesis, making it valuable for malaria research. Beyond its antiparasitic action, it exhibits immunomodulatory and anti-fibrotic effects, with studies highlighting its ability to regulate cytokine production and attenuate tissue inflammation. Isofebrifugine continues to attract interest as a tool for pharmacological research in infectious disease, immunology, and fibrosis-related pathologies.
| CAS Number | 32434-44-9 |
| Synonyms | 3-[[(2S,3aS,7aS)-2-hydroxy-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridin-2-yl]methyl]quinazolin-4-one |
| Molecular Formula | C16H19N3O3 |
| Purity | ≥95% |
| IUPAC Name | 3-[[(2S,3aS,7aS)-2-hydroxy-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridin-2-yl]methyl]quinazolin-4-one |
| InChI | InChI=1S/C16H19N3O3/c20-15-11-4-1-2-5-12(11)18-10-19(15)9-16(21)8-13-14(22-16)6-3-7-17-13/h1-2,4-5,10,13-14,17,21H,3,6-9H2/t13-,14-,16-/m0/s1 |
| InChIKey | YLYLCQRQSRDSQR-DZKIICNBSA-N |
| SMILES | C1CC2C(CC(O2)(CN3C=NC4=CC=CC=C4C3=O)O)NC1 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
