Isofagomine D-Tartrate

For research use only. Not for therapeutic Use.

  • CAT Number: R009129
  • CAS Number: 957230-65-8
  • Molecular Formula: C6H13NO3 • C4H6O6
  • Molecular Weight: 297.3
  • Purity: ≥95%
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Isofagomine (D-<wbr></wbr>tartrate) is a competitive inhibitor of human lysosomal β-<wbr></wbr>glucosidase (K<sub>i</sub> = 0.016-<wbr></wbr>0.025 µM; IC<sub>50</sub> = 0.06 µM). By interacting with the catalytic pocket of β-<wbr></wbr>glucosidase it acts as a chemical chaperone that increases the amount of β-<wbr></wbr>glucosidase by stabilizing and/or promoting the folding of the enzyme. Isofagomine (D-<wbr></wbr>tartrate) has been shown to increase lysosomal β-<wbr></wbr>glucosidase activity by 2-<wbr></wbr> to 3-<wbr></wbr>fold in mutant N370S Gaucher fibroblasts. This compound has been studied in the context of Gaucher disease, a lysosomal storage disorder resulting from substantial deficiency of β-<wbr></wbr>glucosidase and recently identified as a parkinsonism risk factor.


Catalog Number R009129
CAS Number 957230-65-8
Synonyms

(3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol ?(2S,3S)-2,3-Dihydroxybutanedioate

Molecular Formula C6H13NO3 • C4H6O6
Purity ≥95%
Storage -20°C
InChIKey ULBPPCHRAVUQMC-RWOHWRPJSA-N

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