For research use only. Not for therapeutic Use.
Isocitric acid (Cat No.: I042504) is a key intermediate in the citric acid cycle, essential for cellular respiration and energy production. It is an isomer of citric acid, differing in the position of its hydroxyl group. Naturally found in fruits and fungi, isocitric acid plays a role in metabolic pathways, especially in the transformation of carbohydrates, fats, and proteins into energy. In biochemical research, it is used to study enzyme activity, notably isocitrate dehydrogenase, which is critical in mitochondrial function and disease research.
CAS Number | 320-77-4 |
Synonyms | 1-hydroxypropane-1,2,3-tricarboxylic acid |
Molecular Formula | C6H8O7 |
Purity | ≥95% |
InChI | InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13) |
InChIKey | ODBLHEXUDAPZAU-UHFFFAOYSA-N |
SMILES | C(C(C(C(=O)O)O)C(=O)O)C(=O)O |
Reference | [1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720. [2]. Tsuruoka M, et al. Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. [3]. Zupke C, et al. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol. 1995 Dec;44(1-2):27-36. |
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